Journal of Reproductive Health and Contraception

Abstract

Background: Melasma is a common facial pigmentation with multiple treatment options available, however relapses after remission are quite common. Platelet rich plasma (PRP) is a cocktail of various growth factors which are vital for tissue repair and regeneration
Aim of the study: To study the efficacy of platelet rich plasma (PRP) as a monotherapy treatment option in melasma.
Materials and methods: Forty-five patients aged 18-45 years clinically diagnosed as melasma were included as study subjects. Autologous PRP was given intra lesionaly using microinjections at 2, 4 and 6 weeks. MASI score, Patient assessment score (PAS) and Dermoscopy was done at baseline (week 0), 2,4 6 weeks and after 12 weeks. All the patients were prescribed topical sunscreen of SPF 30.
Results: In our study 43 were females and rest were males, giving a female to male sex ratio of 4.65:1. The mean age was 31.7±5.1 years and the mean duration of disease was 4.61±4.3 years. The mean MASI score at baseline was 11.03±5.84 and at 6 and 12 weeks it was 8.7±5.23, 9.44±5.58 respectively, giving a statistically significant (p value 0.00) difference. The results were supported by improvement in PAS and Dermoscopic findings. The most common side effect was pain which subsided within 2-3 hours.
Conclusion: Our study uncovers the potential aspects of PRP as a treatment modality in melasma and also other pigmentary disorders as a mono therapy or as an adjunct therapy.