Journal of Reproductive Health and Contraception

The Effect of Erythropoietin on Endometrial Karyorrhexis during Ischemia Reperfusion Injury in Rats

Aim: This experiment evaluated the influence of erythropoietin in an animal model of uterine ischemia reperfusion using the quoting established protocol. The effects of erythropoietin treatment were evaluated by mean Endometrial Karyorrhexis (EK) lesions. Materials and methods: EK lesions were determined at the 60th reperfusion min (for groups A and C) and at the 120th reperfusion min (for groups B and D). Groups A and B received no drugs, whereas rats from groups C and D were administered with erythropoietin. 40 rats of mean mass 247.7 g were employed for the study. Results: Epo administration non-significantly decreased the EK scores by [without lesions] 0.4 [-0.9640457 - 0.1640457] (p = 0.1242). Reperfusion time nonsignificantly decreased the EK scores by [without lesions] 0.1 [-0.678208 - 0.478208] (P = 0.6729). However, Epo administration and reperfusion time together nonsignificantly decreased the EK scores by [without lesions] 0.2727273 [-0.6102818 - 0.0648273] (p = 0.1102). Conclusions: Epo administration whether it interacted or not with reperfusion time, non-significantly decreased the EK scores in a short-term context of 2 hours.

Author(s):

Τsompos C, Panoulis C, Τοutouzas K, Triantafyllou A, Ζografos G and Papalois A

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