Consumption of colostrum is associated with passive immunity until the immune system of the calf matures in hypogammaglobulinemic calves. The first 24 h of life is highly crucial and calves must obtain immunoglobulins during the period of macromolecular transport, because the colostrum gradually changes to mature milk during the first two days after birth. During this transition, in milk, although the concentrations of the antibodies decrease, milk volume greatly increases. As long as calves consume colostrum will receive immunological protection against many different viruses and bacteria. Therefore, 4 liters of colostrum is commonly recommended to be fed to large breed calves within the first 12 hours of life.
Ozgul Mukaddes E and Bulent E